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Pyrimidyn 7

CAS No. 1440126-94-2

Pyrimidyn 7( Pyrimidyn7 )

Catalog No. M11866 CAS No. 1440126-94-2

Pyrimidyn 7 is a potent, dual-action dynamin GTPase activity inhibitor with IC50 of 1.1 uM/1.8 uM for dynamin I/dynamin II respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Pyrimidyn 7
  • Note
    Research use only, not for human use.
  • Brief Description
    Pyrimidyn 7 is a potent, dual-action dynamin GTPase activity inhibitor with IC50 of 1.1 uM/1.8 uM for dynamin I/dynamin II respectively.
  • Description
    Pyrimidyn 7 is a potent, dual-action dynamin GTPase activity inhibitor with IC50 of 1.1 uM/1.8 uM for dynamin I/dynamin II respectively, competitively inhibits both GTP and phospholipid interactions with dynamin; reversibly inhibits CME of both transferrin and EGF in a number of non-neuronal cell lines as well as inhibiting synaptic vesicle endocytosis (SVE) in nerve terminals; blocks clathrin-mediated endocytosis (CME).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Pyrimidyn7
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Dynamin
  • Recptor
    Dynamin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1440126-94-2
  • Formula Weight
    363.59
  • Molecular Formula
    C21H41N5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCCCCCCCCCCCNC1=NC(=NC(=C1)C)NCCN(C)C
  • Chemical Name
    N2-[2-(Dimethylamino)ethyl]-N4-dodecyl-6-methyl-2,4-pyrimidinediamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. McGeachie AB, et al. ACS Chem Biol. 2013 Jul 19;8(7):1507-18.
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